Table of Contents
What is the relationship between H2CO3 and HCO3?
The dominant acid-base buffer system in humans is the carbonic acid (H2CO3)-bicarbonate (HCO3) buffer system. Gaseous CO2, once dissolved, combines with water to form carbonic acid (dissolved CO2 + H2O -> H2CO3) and dissociates reversibly to yield hydrogen and bicarbonate ions (H2CO3 <- -> H+ + HCO3-).
How do you calculate HCO3 from pH and PCO2?
Henderson Hasselbalch equation
- Normal values: HCO3: 22-26 meq/L. PCO2: 35 – 45 mmHg. pH: 7.35 – 7.45.
- Quick derivation: Carbonic acid (H2CO3) equilibrium: [H+] x [HCO3-] <—> [H2CO3] <—> [CO2] x [H2O] [H+] x [HCO3-] = K x [CO2] x [H2O]
- Final: pH = 6.1 +log (HCO3-/ (0.03 x PCO2))
How do you calculate bicarbonate?
Bicarbonate deficit = 0.2 x weight (kg) x base deficit (mEq/L).
Why is the ratio of bicarbonate to carbonic acid must be at 20 1?
Bicarbonate ions and carbonic acid are present in the blood in a 20:1 ratio if the blood pH is within the normal range. With 20 times more bicarbonate than carbonic acid, this capture system is most efficient at buffering changes that would make the blood more acidic.
What is the formula for HCO3?
HCO3-Bicarbonate / Formula
What is the formula of h2co3?
H₂CO₃Carbonic acid / Formula
How is HCO3 deficit calculated?
How do you calculate HCO3 concentration?
Rearrange this equation to solve for [HCO3-]. Since pH = -log [H+], [H+] = 10 to the negative pH. We can use this information and some algebra to rewrite the equation as [HCO3-] = ( 2 x total alkalinity ) – ( 10 to the (-14 + pH) ) / ( 1 + 2K2 x 10 to the pH).
What is HCO3 in chemistry?
Bicarbonate, also known as HCO3, is a byproduct of your body’s metabolism. Your blood brings bicarbonate to your lungs, and then it is exhaled as carbon dioxide. Bicarbonate is excreted and reabsorbed by your kidneys. This regulates your body’s pH, or acid balance.
How does carbonic acid turn into bicarbonate?
On the venous side of systemic capillaries CO2 enters red blood cells (RBC) where it combines with water to form carbonic acid (H2CO3). This reaction is catalyzed by the enzyme carbonic anhydrase (CA) which is found in RBC’s. Carbonic acid then dissociates to form bicarbonate ions (HCO3-) and hydrogen ions (H+).